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Home   >   Cartilage   >   Arthro-5

180 capsules of 763 mg

30-day supply

- Contents and dosage
Read more


  • Most potent supplement in the world in its category

  • High dosages of glucosamine, chondroitin, MSM, ASU and hyaluronic acid

  • Branded ingredients only
  • Pharmaceutical grade
  • Independently tested by NutriControl laboratory

Arthro-5 is our most popular supplement. That says it all.

180 capsules of 763 mg

30-day supply

- Contents and dosage
Home   >   Cartilage   >   Arthro-5

Unique composition

For the development of Arthro-5, exercise physiologist Kris Kuiper reviewed various well-known and lesser-known ingredients. In consultation with scientist colleagues and based on their collective findings, 6 ingredients which complement each other particularly well were finally selected. 

The combination of these ingredients and the use of the proper, high dosages make Arthro-5 a unique product and the ultimate dietary supplement for joint cartilage protection worldwide! It offers the highest chance of benefit and is therefore very popular among our customers. 

Arthro-5 contains the well-known ingredients glucosamine, chondroitin, MSM, and vitamin C as well as the lesser-known but no less important ASU and hyaluronic acid. Some of these substances are produced naturally in the human body. They are important building blocks for cartilage, joint capsule, tendons, and other connective tissue. It is possible to replenish these substances by means of supplements. In Arthro-5 they are combined in one product which is hence the most complete and potent supplement. 

Read more about the composition of Arthro-5 below.

1. Glucosamine sulphate (GlucosaGreen®)
1500 mg per daily dose

Most utilised joint protection substance in the world - and for good reason. Glucosamine helps in maintaining cartilage, joint casings, tendons and other connective tissues. It also contributes to the maintenance of joint fluid, thus supporting joint lubrication. And Arthro-5 contains the proper, high dosage of 1500 mg of glucosamine per day.

2. Chondroitin sulphate
1200 mg per daily dose

Valuable ingredient that reinforces glucosamine. Even more important is the fact that chondroitin protects the cartilage by keeping a few key enzymes in balance. Glucosamine and chondroitin thereby complement each other excellently. Scientific research now shows that taking both supplements at the same time significantly enhances results. 

3. ASU (AvoVida®)
300 mg per daily dose

Specially processed extract of avocado and soy oil. Despite extremely persuasive scientific evidence, ASU is still a relatively unknown supplement in most countries after glucosamine and chondroitin. Among other benefits, it can promote the creation of collagen, which contributes to cartilage strength.

4. MSM (OptiMSM®)
1500 mg per daily dose 

Popular with the public for years, but repudiated for many years by the scientific community. In the meantime scientific support for the use of MSM has grown: it has a beneficial influence on joints. Adding it to glucosamine leads to faster and better results. 

5. Hyaluronic acid (HAPLEX®  Plus)
80 mg per daily dose 

A relatively new nutritional supplement. Hyaluronic acid is the most important component of the lubricating fluid in the joints. It also enables our joints to absorb shocks. For this reason, doctors have been giving injections with hyaluronic acid directly into the joints for almost 20 years. It has now also been established that it has a beneficial physiological influence as a nutritional supplement as well. It is important to note that only hyaluronic acid with a high molecular weight is useful. A lot of (cheap) hydrolised hyaluronic acid is available. Its molecular weight is much lower, with the result that its effect is counterproductive. 

6. Vitamin C
18 mg per daily dosage 

Vitamin C contributes to normal collagen formation and hence to normal cartilage function. 

---- has been licensed to use the patented combination of chondroitin and ASU (EP2101799).

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Correct dosage guaranteed

The optimal (effective and safe) dosage of the ingredients in Arthro-5 is determined on the basis of thorough research by means of scientific investigations. This cannot be taken for granted, unfortunately. There are many reasons for supplement manufacturers and sellers to use a different dosage to the one endorsed by science. We explain the most important reasons below.

Because ingredients are often expensive, it is attractive for a provider of dietary supplements to save money on the dosage. Halve the dosage and you will practically halve the cost. The profit margin will rise substantially.

In scientific studies on the effect of for instance chondroitin, it has been determined that a daily dosage of 800 mg or 1200 mg is physiologically effective. We use that highest dosage. In many products, however, lower quantities of this expensive ingredient are used: 600 mg, 250 mg, even 50 mg! You can be sure that the ingredient in the last quantity is only used to decorate the label. It looks good, but to the user it is worthless.

Read more below about other causes of low dosages. 

Too many capsules 

The optimal dosage is often a high dosage (except in the case of vitamins). For that high dosage many capsules are needed, which not all users are happy with. Some producers therefore choose a lower dosage. 

MSM is an ingredient which is regularly added to products for joint cartilage in a dosage that is too low. The minimum daily amount required is 1500 mg. For this only, 1.5 capsules are needed, and often 1500 mg of glucosamine and 1200 mg of chondroitin have yet to be added. For just these three ingredients 4-5 capsules must be taken, which is not easy to 'sell' as a daily dosage. 

Products with a dosage of 1500 mg of MSM or more are not easy to find. The dosage is usually a couple of hundred mg. Good because there are less capsules to take, not good because the effect will also be less. 

At we understand the preference for having to take less capsules. We nevertheless consider it more important to provide the proper dosage than a dosage which is easier to take but which is of less use. It is for this reason that we use 1500 mg of MSM in our Arthro-5 product. Together with the other likewise highly dosed ingredients, this means a daily quantity of 6 capsules. Not everyone is happy with that. But isn't the result what counts? 

Lack of knowledge 

Even if a provider chooses the proper, scientifically endorsed dosage, this is no guarantee that this is the dosage that will end up in the product. Glucosamine sulphate, for instance, is a product which is regularly administered in too low a dosage, usually due to ignorance. 

Research has shown that 1500 mg of glucosamine sulphate per day is a physiologically effective dosage. A provider that is not familiar with the product glucosamine sulphate will not know that glucosamine sulphate is stabilized with a salt. If the company does not take this into account, it will provide 1500 mg including that salt. After deducting the salt, there will be 24% less left. This is unfortunately all too common. 

Chondroitin is also an ingredient which is unknowingly regularly administered in too low a dosage. The best chondroitin has a purity of 90-95% at the most (100% cannot be achieved in practice). We are one of the few providers that correct for the missing percentage and deliver 1350 mg so that 1200 mg of pure chondroitin can be guaranteed.

Legal restrictions 

In some countries legal restrictions are imposed on the dosages of dietary supplements. Italy and Germany are two of those countries. Those enforced lower dosages have nothing to do with safety. Their only objective is to make the supplement less effective. 

They came into being under the influence of industrial lobbies of companies that have an interest in people taking less or no dietary supplements. They see effective supplements as competition for their products. With an enforced lower, less effective dosage, that competition is eliminated. 

In the Netherlands, where we are based, these restrictions fortunately do not apply.

Quality of Arthro-5

Proper, high dosage

GMP certified

Laboratory tested

Specialist since 2000

By choosing Arthro-5 you are choosing quality. We can guarantee it in the following way: 

Safe product. These Western producers fulfill GMP and HACCP requirements. This means that they follow strict procedures which ensure food safety and hygiene. 

Independently tested. The end product is randomly tested for heavy metals and biological pollutants by the independent laboratory NutriControl. Click on the microscope symbol below for the most recent test results. Read more about the independent laboratory tests here.

Proper, high dosage. Many dietary supplements contain dosages that are too low and ineffective. Arthro-5 contains the proper, high dosages. This is the reason that the daily dosage is 6 capsules (which may be taken simultaneously). 

Capsule form. Arthro-5 comes in capsules instead of tablets. Capsules are absorbed more quickly and have less chance of causing gastric hypersensitivity. Another advantage of capsules is that they are easier to swallow than rough capsules with hard edges. Whoever does not want to or cannot take the capsules, can easily open them and use only the powder. 

Specialist since 2000. is a specialist in dietary supplements for healthy joints. The company was founded in 2000 by exercise physiologist and human movement scientist Kris Kuiper and has developed several unique supplements since then. Plenty of knowledge and experience is available about the effect and the safety of these supplements.

  • Proper, high dosage of each ingredient
  • Pharmaceutical grade
  • Safe product: produced by companies which are GMP and HACCP certified
  • Independently tested for quality by NutriControl laboratory
  • Capsule form: better tolerated, better absorbed and easier to swallow than tablets
  • Specialist in joint supplements since 2000
Independently tested for quality by NutriControl laboratory

Duration of use

The effect of Arthro-5 can usually be noticed within one to two months, but sometimes it is possible to notice the effect after shorter periods such as a week or longer periods of up to six months. This can vary from one individual to the next. 

We recommend trying out Arthro-5 for at least three months. After that period the supplement can be evaluated to decide whether it would be useful to continue taking it. Most people come to the conclusion that it is worth taking longer and take Arthro-5 continuously. There is no problem with that. It can be taken safely for years.

Arthro-5 is not our cheapest product. Still, the price that you pay for this supplement is very competitive, given its many highly-dosed high-quality ingredients. A 'normal' price structure would result in a product with comparable ingredients having a retail price of €75 / £75. 

If the costs are still cause for objection, Arthro-5 can be alternated with for instance our separate supplements glucosamine sulphate and chondroitin sulphate.



Less acute

Eduardo Gonzalez, July 5, 2024
After six months of treatment with Arthro-5 the symptoms of *** in both hands are less acute. Clearly the progression of the *** has slowed down and I continue the treatment with the hope that it will stop completely and maybe even reverse.
On a website which sells supplements, those supplements can not be associated with the treatment of diseases. This is why some words have been left out in this review. We apologize for the inconvenience.

I really notice

Kerryn Radovan Coulter, October 20, 2023
I really notice whether I take this supplement or not. I can recommend it.

These products work

David Lapointe, October 8, 2023
I've tried 1 bottle and 4 caps along with my 1500 mg of glucosamine for one month and I'm saying these products work for tendons and knee ***. With the Arthro-5 my knee *** was reduced to a near zero. Try It, You Might Love it! Rockman2112 --- Response It's very good to hear that you like Arthro-5 and glucosamine. It's important though not to use these products together for prolonged periods. Arthro-5 already contains 1500 mg of glucosamine per daily dose of 6 capsules (in your case 1000 mg per 4 capsules). Adding another 1500 mg of glucosamine is not recommended.
On a website which sells supplements, those supplements can not be associated with the treatment of diseases. This is why some words have been left out in this review. We apologize for the inconvenience.

Definitely worth the cost and daily tablet routine

Mike Jones, June 19, 2023
I started taking Arthro-5 about 3 years ago, yes it's a big commitment, 6 tablets a day and quite expensive, BUT what a difference to my knees. I have 40 steps up to my front door and I was finding my knee would give way and be quite ***, years of running I guess. Now I have absolutely no *** or movement issues and have happily ordered my next 3 months supply. It's definitely worth the cost and the daily tablet routine :-)
On a website which sells supplements, those supplements can not be associated with the treatment of diseases. This is why some words have been left out in this review. We apologize for the inconvenience.

Got me back on the road to recovery

Andrew James, April 10, 2023
Used this product many years ago after two knee operations and helped a lot with recovery and got me back on the road to recovery.
More reviews

Satisfied with your choice for

Contents and information for use


180 capsules.

Contents per capsule (per 6 capsules): 

  • Glucosamine sulphate - 250 mg (1500 mg), equivalent to 198 mg (1190 mg) of glucosamine base
  • MSM - 250 mg (1500 mg)
  • Chondroitin sulphate - 200 mg (1200 mg)
  • ASU - 50 mg (300 mg)
  • Hyaluronic acid - 13.3 mg (80 mg)
  • Vitamin C - 3 mg (18 mg)


  • Glucosamine sulphate (GlucosaGreen)
  • (OptiMSM)
  • Chondroitin sulphate (TSI)
  • ASU (AvoVida)
  • Bovine gelatin (capsule)
  • Potassium chloride (as stabilizer)
  • Rice starch (filler)
  • Hyaluronic acid (HAPLEX Plus)
  • Magnesium stearate (flowing agent)
  • Vitamin C (ascorbic acid)
  • Colourings E122 and E151 (capsule)
  • Silicon dioxide

The glucosamine is extracted from glucose from corn (not genetically modified). Chondroitin is a cartilage extract that comes from beef. ASU is extracted from soy and avocado (not genetically modified). MSM is a natural sulphur compound. hyaluronic adid is a cartilage extract from poultry.

Allergens: Soy.

Free of gluten, milk and lactose.


The recommended use is 6 capsules of Arthro-5 per day. 

The capsules may be taken simultaneously or distributed throughout the day. It is preferable to take the capsules at mealtime(s) or with plenty of water. 

Do not surpass the maximum recommended dosage. Dietary supplements must not be used as a substitute for a varied diet. 

Do you have difficulty swallowing capsules? You can open the capsule by separating the two halves and just use the powder. You can combine it with water, fruit juice, or yoghurt, for instance.


The ingredient glucosamine in Arthro-5 can have an influence on the action of certain blood thinners (vitamin K antagonists). Do not take this supplement in combination with this type of medication without consulting a doctor. Other blood thinners such as aspirin do not pose a problem.

Do not take during antibiotic treatment. 

Do not take if you suffer from glaucoma (increased eye pressure). 

Do not take during pregnancy or the breastfeeding period. 

Diabetics must check their blood sugar level during the first weeks of use. 

Read more about the safe use of Arthro-5 below.

Safe use

Arthro-5 can be taken safely for a long time. It does not have any serious side effects, in contrast to many painkillers. There is no problem even if it is taken for years. 

Research into long-term use (2-3 years) of the ingredients in Arthro-5 has not identified any serious side effects. There are no indications that even longer use would not be safe. Many of the ingredients have been available as dietary supplements for decades. During that period, no serious side effects have ever been reported. 

Some precautions must be taken in certain conditions and if taking certain medicines. You will find more information below.

Blood thinners 

The ingredient glucosamine in Arthro-5 can have an influence on the action of certain blood thinners (vitamin K antagonists). Do not take this supplement in combination with this type of medication without consulting a doctor. Other blood thinners such as aspirin do not pose a problem.


The ingredient glucosamine can have an influence on the effect of some antibiotics - it can increase or reduce the effect. We recommend not to take Arthro-5 during antibiotic treatment. 

Glaucoma (increased eye pressure) 

In July 2013, the results of a small study on the effect of the ingredient glucosamine on patients with glaucoma (increased eye pressure) were published. The test subjects are 6 men and 11 women with an average age of 76 years (62 to 90 years of age). The study identified that the supplement can increase eye pressure in most of these patients. Suspending its use allows the eye pressure to drop again. The average difference in eye pressure measured is 3 mm Hg. 

Since this is a small study, its design does not comply with a number of important guidelines for scientific research. The scientists also indicate that the study must be confirmed with a larger, better-designed study. Nevertheless, we assume that the effect is real and therefore give the following advice: 

If you have glaucoma we recommend that you do not take Arthro-5. A second possibility is to have the eye pressure measured several times once you have started taking it. Important: this precaution is only for people who already have glaucoma. There are no indications that Arthro-5 can result in increased eye pressure in healthy people. 

If you are looking for an alternative, try ASU Forte or Chondroitin. These two supplements do not have an effect on glaucoma. They can be combined for an even better result. 

Diabetes type 2 (adult-onset diabetes) 

There are indications that blood sugar level can be affected in people with diabetes type 2 (adult-onset diabetes) during use of the ingredient glucosamine. We therefore recommend that diabetes patients regularly check their blood sugar level when they start taking Arthro-5. 

Another possibility is to choose an alternative supplement. Neither ASU Forte nor Chondroitin affect people with diabetes type 2. These two supplements can be combined for an even better result. 

Potassium-restricted diet 

The ingredient glucosamine is stabilized with potassium chloride. A daily dosage (6 capsules) contains 268 mg of potassium. This is slightly more than the quantity of potassium in half a banana or 4 slices of wholegrain bread. An increased intake of potassium can however have adverse effects in people with seriously impaired kidney function. The intake of potassium must also be restricted if taking potassium-sparing medicines. 

Gastrointestinal hypersensitivity 

The ingredient glucosamine is a substance which is naturally present in the body. No serious side effects have ever been observed. The mild side effects which occur in some people usually reflect gastrointestinal hypersensitivity. Nausea and excess gastric acid are the usual effects in those cases. Constipation or, conversely, diarrhoea, occur less frequently. Nausea and excess gastric acid can in general be prevented by taking Arthro-5 during or soon after meals. 


Do not take Arthro-5 if you are pregnant, have the intention to become pregnant, or are breastfeeding. The supplement has a very favourable safety profile but no studies have been carried out which can rule out a possible adverse effect on the (unborn) child. 

Use at a young age 

Use by children and teenagers (up to 18 years of age) is discouraged. As a guiding principle, the body must be 'fully grown' in order to start taking it. 'Fully grown' refers to both bone development and hormonal development. The reason that we make this recommendation is that no research has been carried out to determine whether it is safe for children and teenagers.

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